摘要
垂體腺瘤在內科臨床病例中並不罕見，其中一半以上是功能性腺瘤。近年來由於對垂體功能性腺瘤分泌之機轉及相關荷爾蒙作用受器分子結構之了解，有多種作用在腫瘤細胞抑制性藥物在臨床上應用。因而內科醫師在功能性垂體腺瘤扮演角色益形重要。以促乳素瘤而言藥物使用已成第一線之治療方式。內科醫師對功能性垂體腺瘤之治療方式應包括治療或術前之評估。整體之評估除臨床表徵完整記錄、神經學之檢查；在影像上包括腺瘤對腦部神經、血管之壓迫及完整之內分泌系統功能評估、基礎荷爾蒙之檢查及進一步必要之動態荷爾蒙檢查，不論患者接受內外科治療方式，以病患為主之長期評估不論垂體功能低下或體內代謝疾病及併發症之發生均須有完整之考量。如此才可能對患者提出長遠之治療計畫。
並列摘要
Cases of pituitary tumors are not unusual in medical wards or clinics. Over half of these cases are functional pituitary tumors. During recent years, with the elucidation of the secretion mechanism of functional pituitary tumors and the molecular structures of receptors and agonists, many new drugs were developed as antagonists of pituitary tumors. In the past decade, doctors of internal medicine played more important roles in the treatment of functional pituitary tumors. Medical treatment was considered as the first line of treatment for prolactinomas. For patients with functional pituitary tumors, preoperative functional evaluation, complete recording of clinical presentation, neurological examination, and complete imaging studies are important before treatment. Measurement of baseline hormone levels and dynamic functional evaluation before and after medical or surgical treatments are important. Therapeutic goals for functional pituitary tumors are alleviation of tumor mass effects and maintenance of normal pituitary functions in the patients.