摘要
非酒精性脂肪胰疾病(non-alcoholic fatty pancreas disease, NAFPD)，簡稱脂肪胰(fattypancreas)是指因肥胖、非酒精攝取過多造成過多的胰臟脂肪堆積。利用非侵入性影像如：腹部超音波、內視鏡超音波、電腦斷層掃描和磁振造影可容易偵測到是否有胰臟脂肪浸潤。胰臟脂肪變性與肥胖、代謝症候群有高度相關，可能是代謝症候群一個有意義的臨床表徵。脂肪胰可能也與糖尿病、脂肪肝、以及胰臟外分泌失能相關。近年來，胰臟脂肪浸潤逐漸受到重視，然而，非酒精性脂肪胰疾病與這些慢性疾病之間的致病機轉、對人體的影響、臨床上的意義、以及外分泌胰腺功能的影響等仍不完全清楚，有待更多醫學研究來解答。
並列摘要
Unlike fat stored in subcutaneous adipocytes, visceral fat and ectopic fat stored in tissues such as liver, heart, muscle, and pancreas are both associated with obesity and/or insulin resistance. Fatty liver is reported to be associated with insulin resistance, dyslipidemia, and obesity and is therefore considered a phenotype of metabolic syndrome. Fatty pancreas or nonalcoholic fatty pancreatic disease (NAFPD) is an excessive fat infiltration of the pancreas due to obesity in the absence of significant alcohol intake. NAFPD is highly associated with obesity and metabolic syndrome, and may represent a meaningful manifestation of metabolic syndrome. It might also be associated with diabetes, fatty liver, and pancreatic exocrine dysfunction. The association between fatty pancreas and pancreatitis, pancreatic adenocarcinoma was controversial. NAFPD has recently gained much attention. However, the pathogenesis linking fatty pancreas and chronic metabolic diseases, exocrine dysfunction, and its clinical implications and consequences remained unclear. Further basic science and clinical researches of fatty pancreas should be carried out.
延伸閱讀
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