The purpose of this research is to develop a new Masked Photopolymerization Rapid Prototyping (MPRP) System using liquid crystal displayer (LCD) panel. The design concept of the MPRP system is to use a dynamical photo mask for the layer profile. The layer pattern of the dynamic mask, generated by a thin film transistor liquid crystal displayer (TFT LCD) panel, is calculated from the slicing data of the CAD model. The generated layer pattern is then exposed on the liquid visible photocurable resin for solidifying a layer thickness. The process is also then repeated until the part is completely with each new layer bonding to the previous layer. As a result, the prototype is fabricated on the platform. For the purpose of evaluating its performance and application, a standard turbine blade and a tooth model prototype for the replication of the orthodontic aligner are built by the developed MPRP system. Consequently, the complex feature of turbine blade can be easily fabricated with high speed. The process of MPRP system has been applied successfully into reproduce clinical orthodontic aligner for patient.