六磨湯治療慢性機能性便秘之研究

Evaluation of "Liu Mo Tang" for Chronic Functional Constipation

王煌輝(Hwang-Huei Wang) ； 李榮貴(Jong-Kuei Lee)

《中醫藥雜誌》 8卷2期 (1997/06) Pp. 65-72

https://doi.org/10.6940/JCM.199706_8(2).01

摘要

Twenty eight chronic functional constipation subjects were prospectively randomized into experimental group (herb group, n=16, mean age=35.3±2.5) and control group (n=12, mean age=32.0±4.5) at division of gastroenterology, China Medical College Hospital from July 1991 to September 1992. Females were predominant in both groups, only 2 of 28 subjects were male in this study. The herb group was treated with ”Liu Mo Tang” (L.M.T.), 4 g twice daily for 8 weeks, and control group was treated with Eucarbon 2 tablets twice daily for 8 weeks. Parameters for evaluation included fecal frequency, fecal consistency and the symptoms of constipation. Before treatment, 17 out of 28 subjects were evaluated with total bowel transit time (TBTT). The mean TBTT was 76.1±4.8 hours. The result of this study indicated that the fecal frequency had increased from 1.56±0.11 per week to 1.31±0.09 per day after treatment in herb group and from 1.83±0.17 per week to 1.22±0.09 per day in control group. In addition, the fecal consistency were changed from stony hard 81.3% (13/16) to soft 75% (12/16) in herb group and 91.6% (11/12) to 66.7% (8/12) in control group. Significant improvement (p＜0.05) of tenesmus and dizziness in both group was noted. Improve went in abdominal pain, fullness, belching, chest tightness, and anorexia in the experimental group showed that the herbal treatment was significantly more effective. The frequency of adverse effects including abdominal cramping, anorexia and chest tightness was 1/16 in herb group and 4/12 in control group. Complete recovery from functional constipation was 3/16 in herb group and 1/12 in control group. Excellent response were 7/16 vs 5/12 and partial response were 6/1 vs 6/12 in herb group and control group respectively. Our results indicated that L.M.I. was better than Eucarhon in treatment of chronic functional constipation.

關鍵字

六磨湯 ； 慢性機能性便秘

並列摘要

Twenty eight chronic functional constipation subjects were prospectively randomized into experimental group (herb group, n=16, mean age=35.3±2.5) and control group (n=12, mean age=32.0±4.5) at division of gastroenterology, China Medical College Hospital from July 1991 to September 1992. Females were predominant in both groups, only 2 of 28 subjects were male in this study. The herb group was treated with ”Liu Mo Tang” (L.M.T.), 4 g twice daily for 8 weeks, and control group was treated with Eucarbon 2 tablets twice daily for 8 weeks. Parameters for evaluation included fecal frequency, fecal consistency and the symptoms of constipation. Before treatment, 17 out of 28 subjects were evaluated with total bowel transit time (TBTT). The mean TBTT was 76.1±4.8 hours. The result of this study indicated that the fecal frequency had increased from 1.56±0.11 per week to 1.31±0.09 per day after treatment in herb group and from 1.83±0.17 per week to 1.22±0.09 per day in control group. In addition, the fecal consistency were changed from stony hard 81.3% (13/16) to soft 75% (12/16) in herb group and 91.6% (11/12) to 66.7% (8/12) in control group. Significant improvement (p＜0.05) of tenesmus and dizziness in both group was noted. Improve went in abdominal pain, fullness, belching, chest tightness, and anorexia in the experimental group showed that the herbal treatment was significantly more effective. The frequency of adverse effects including abdominal cramping, anorexia and chest tightness was 1/16 in herb group and 4/12 in control group. Complete recovery from functional constipation was 3/16 in herb group and 1/12 in control group. Excellent response were 7/16 vs 5/12 and partial response were 6/1 vs 6/12 in herb group and control group respectively. Our results indicated that L.M.I. was better than Eucarhon in treatment of chronic functional constipation.

並列關鍵字

Chronic functional constipation ； Liu Mo Tang