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臺灣金線連水粗萃取物對大鼠90天餵食毒性作用

Effects of 90-Days' Repeated Oral Administration of Crude Extract of Anoectochilus Formosanus Hayata on Rats

摘要


本實驗主要探討臺灣金線連水粗萃取物連續經口投與90天對大鼠的毒性作用。臺灣金線連水粗萃取物使用的劑量爲每天投與0.5 g/kg或2.0 g/kg。雄性大鼠2.0 g/kg組體重減輕。血液學檢查:雌性大鼠2.0g/kg組出現中性球減少情形。血清生化學檢查:雌性大鼠2.0 g/kg組的乳酸去氫西每活性及鈣、磷濃度下降。尿液分析:雄性大鼠2.0 g/kg組出現輕微酮尿。臟器重量:雌性大鼠2.0g/kg組的腦下垂體、腎臟、肝臟增重,子宮減重,但並無實質上的病理組織變化。大鼠長期投與臺灣金線連水粗萃取物,安全劑量在0.5 g/kg以下。

並列摘要


Subacute toxicity study was carried out by administering orally daily doses of 0, 0.5 and 2.0 g/kg of crude extract of Anoectochilus formosanus Hayata (AFE) to groups of male and female rats for 90 days. At the dose of 2.0 g/kg, retardation of weight gain and slight increase in urinary ketones were noted in the males while decreased numbers of segmented neutrophils, decrease in serum lactate dehydrogenase activity, slight decrease in serum calcium and phosphorus levels, and increase in tissue weights of the pituitary, liver and kidney were observed in the females. However, no accompanying histopathological changes were observed. In conclusion the dose with which no toxicological manifestations were associated was likely 0.5 g/kg or below.

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