New Ergostane and Lanostane from Antrodia Camphorata

牛樟芝成分之研究

沈建昌(Chien-Chang Shen) ； 郭育綺(Yuh-Chi Kuo) ； 黃瑞齡(Ray-Ling Huang) ； 林麗純(Lei-Chwen Lin) ； 董明兆(Ming-Jaw Don) ； 張東柱(Tun-Tschu Chang) ； 周正仁(Cheng-Jen Chou)

《中醫藥雜誌》 14卷4期 (2003/12) Pp. 247-258

https://doi.org/10.6940/JCM.200312_14(4).04

摘要

樟薄孔菌(Antrodia camphorate)又名牛樟芝或樟芝，為台灣特有真菌，生長在台灣本土特有牛樟樹(Cinnamomum kanehirae)上，民間傳頌牛樟芝具有藥食物中毒之解毒作用，亦可治療腹瀉、肚子痛，高血壓，皮膚癢，及肝癌等。經本次實驗研究，從牛樟芝子實體酒精抽取物分離出十四種成分，分別為3β,15α-dihydroxylanosta-7,9(11),24-trien-21-oic acid、antcin K、dehydroeburicoic acid、eburicoic acid、methyl antcinate B、methyl antcinate H、zhankuic acid A、zhankuic acid B、dehydrosulphurenic acid、sulphurenic acid、15α-acetyl-dehydrosulphurenic acid、versisponic acid D、zhankuic acid C、和2,2',5,5'-tetramethoxy-3,4,3',4'-bis(methlylenedioxy)-6,6'-dimethylbiphenyl。其中四種成分3β,15α-dihydroxylanosta-7,9(11),24-trien-21-oic acid (1)、antcin K(2)、sulphurenic acid 及versisponic acid D，係首次從牛樟芝獲得，成分1及2兩種更是首次在天然物界發現。

關鍵字

牛樟芝 ； 真菌 ； 麥角甾酸 ； 羊毛甾酸 ； 雙苯環類

並列摘要

Fourteen compounds (one biphenyl, six ergostane, and seven lanostane derivatives) have been isolated from the fruiting body of Antrodia camphorata. They are 3β, 15α-dihydroxylanosta-7, 9 (11), 24-trien-21-oic acid, antcin K, dehydroeburicoic acid, eburicoic acid, methyl antcinate B, methyl antcinate H, zhankuic acid A, zhankuic acid B, dehydrosulphurenic acid, sulphurenic acid, 15α-acetyl-dehydrosulphurenic acid, versisponic acid D, zhankuic acid C, and 2, 2', 5, 5'-tetramethoxy-3, 4, 3', 4'-bis (methlylenedioxy) -6, 6'-dimethylbiphenyl. Among them, two lanostane-type compounds-sulphurenic acid and versisponic acid D were not previously reported from this fungus. 3β, 15α-Dihydroxylanosta-7, 9 (11), 24-trien-21-oic acid and antcin K are first found from nature and their structures were determined by spectroscopic methods.

並列關鍵字

Antrodia camphorate ； Fungi ； Ergostane ； Lanostane ； Biphenyl derivatives