冬蟲夏草人工培養菌絲體對人體嗜中性血球及T淋巴球免疫反應之影響

Effect of Cultured Mycelia Cordyceps Sinensis on Neutrophil and T- Cell- Mediated Immune Response in Humans

徐佳吟(Chia-Ying Hsu) ； 陳俊良(Jiun-Liang Chen) ； 楊賢鴻(Sien-Hung Yang)

《中醫藥雜誌》 22卷3&4期 (2011/12) Pp. 161-172

https://doi.org/10.6940/JCM.201112_22(3_4).04

摘要

Cordyceps sinensis is known as a medicinal herb that can be used to enhance chi and kidney function in Traditional Chinese medicine that was commonly used by folks in treating inflammatory diseases such as chronic nephritis and brochitis. The purpose of this study was to investigate the anti-inflammatory effects of cultured Cordyceps sinensis on neutrophil- and T lymphocyte- mediated immune responses. In the present study, we recruited healthy volunteers to randomly take either 1.5 gm of mycelium of cultured Cordyceps sinensis or placebo twice daily for three months. Blood samples were collected from volunteers to define their phagocytotic function of neutrophils, PGE2 level and LTC4 level produced by neutrophils as well as CD4/CD8 ratio of T lymphocytes before the study, and monthly, until the third month when the study completed. In the experimental group treated with cultured Cordyceps sinensis, neutrophil phagocytosis decreased significantly (P＜0.05). After 100 μg/ml lipopolysaccharide incubation, the amount of PGE2 produced by neutrophils also decreased significantly (P＜0.05). Three months treatment with cultured Cordyceps sinensis significantly increased CD4/CD8 ratios. In summary, cultured Cordyceps sinensis significantly decreased the phagocytotic function of neutrophils, inhibited cyclooxygenase pathway and increased CD4/CD8 ratios. We concluded that the mycelium of cultured Cordyceps sinensis has a moderate anti-inflammatory effect.

關鍵字

冬蟲夏草 ； 嗜中性白血球 ； 前列腺素 ； 單核淋巴球

並列摘要

Cordyceps sinensis is known as a medicinal herb that can be used to enhance chi and kidney function in Traditional Chinese medicine that was commonly used by folks in treating inflammatory diseases such as chronic nephritis and brochitis. The purpose of this study was to investigate the anti-inflammatory effects of cultured Cordyceps sinensis on neutrophil- and T lymphocyte- mediated immune responses. In the present study, we recruited healthy volunteers to randomly take either 1.5 gm of mycelium of cultured Cordyceps sinensis or placebo twice daily for three months. Blood samples were collected from volunteers to define their phagocytotic function of neutrophils, PGE2 level and LTC4 level produced by neutrophils as well as CD4/CD8 ratio of T lymphocytes before the study, and monthly, until the third month when the study completed. In the experimental group treated with cultured Cordyceps sinensis, neutrophil phagocytosis decreased significantly (P＜0.05). After 100 μg/ml lipopolysaccharide incubation, the amount of PGE2 produced by neutrophils also decreased significantly (P＜0.05). Three months treatment with cultured Cordyceps sinensis significantly increased CD4/CD8 ratios. In summary, cultured Cordyceps sinensis significantly decreased the phagocytotic function of neutrophils, inhibited cyclooxygenase pathway and increased CD4/CD8 ratios. We concluded that the mycelium of cultured Cordyceps sinensis has a moderate anti-inflammatory effect.

並列關鍵字

Cordyceps sinensis ； neutrophil ； prostaglandin ； lymphocyte