當歸對乳癌預後之影響：文獻回顧研究

The Effects of Dang-qui on the Prognosis of Breast Cancer: A Systematic Review Study

侯俊成(Chun-Cheng Hou) ； 羅元君(Yuan-Chun Lo) ； 陳柏旭(Bo-Syu Chen) ； 劉千鈺(Chien-Yu Liu) ； 陳瑩陵(Ying-Ling Chen) ； 呂友文(Yu-Wen Lu)

《中醫藥雜誌》 28卷2期 (2017/12) Pp. 75-82

https://doi.org/10.3966/241139642017122802007

摘要

前言：由於當歸具有雌激素作用，因此可能對乳癌預後有不良影響。然而當歸長期使用於中醫臨床及食品，根據辨證論治也運用於乳癌治療。本文擬以系統性文獻回顧方法來探討乳癌病人是否需避免服用當歸。方法：搜尋PubMed，以breast cancer分別和Angelica sinensis（當歸）和Dang gui（當歸）做交集，時間至2016年7月為止，所篩選之文獻刪除與本次主題無關及重複文章後，再由兩位中醫師分別加以評讀，針對當歸對乳癌之影響分類為有利、不利及其他，意見不一致之文獻則再由一位資深中醫師評讀，最後分類結果依照證據等級列表繪圖。結果：篩選後共得12篇，有利6篇，不利3篇，3篇為其他。結果顯示支持可以使用當歸之研究，其證據等級及數量高於不支持之研究。結論：服用當歸對於乳癌患者正面影響高於負面，因此臨床可依據中醫治療原則適當給予患者使用。

關鍵字

當歸 ； 乳癌 ； 中醫

並列摘要

Objectives: Previous researches showed the negative effects of Dang gui on the prognosis of breast cancer, thus the patients were advised not to take this Chinese herb. However Dang gui is widely used not only in food, but also in herbal remedies for very long time. This study underwent a systematic review to evaluate the effects of Dang gui on patients with breast cancer. Methods: We search PubMed by using breast cancer and the MeSH terms about Angelica sinensis and Dang gui. The end time is July, 2016. After ruling out the duplicating research or inappropriate topic, there were two traditional Chinese medicine (TCM) doctors to do critical appraisal. The results were separated favorable effect, poor effect or others. The other senior TCM doctor did critical appraisal about the disagreement studies. And the result would be classified to different categories by level of evidence. Results: There are 6 of those studies are favorable effect, 3 are poor effect, 3 are other. There were higher level of evidence and more amount about those studies favor using Dang gui. Conclusions: There are lots of high-level evidence studies with positive suggestion about the effect of Dang gui on patients with breast cancer. The patients with breast cancer can take Angelica sinensis under proper TCM managements.

並列關鍵字

Dang-qui ； breast cancer ； traditional Chinese medicine

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