動脈內灌注化學療法對原發性肝癌之療效評估

INTRA-ARTERIAL INFUSION CHEMOTHERAPY FOR HEPATOMA

楊建芳(C. F. Yang) ； 黃巖華(Y. H. Hwang) ； 姜仁惠(J.H. Chiang) ； 王家槐(J.H. Wang) ； 吳峻吉(C. C. Wu) ； 陳啓明(C. M. Chen) ； 劉自嘉(T.J. Liu) ； 黎國洪(K.H. Lai) ； 李壽東(S.D. Lee)

《中華放射線醫學雜誌》 8卷3期 (1983/09) Pp. 227-234

摘要

榮總從70年10月到72年1月共有26位病理症實爲原發性肝癌的患者接受動脈内注化學藥物治療。每位病人均給予5-FU，adriamycin及mitomycin-C三種藥物，同時定期作超音波，電腦斷層掃描及血管攝影檢査來評估療效。26位病人中男性24人，女性2人，年齡從15歳到74歳，平均爲56.6歳。17位經病理證實有肝硬化。大部份病人接受治療之後症狀均有改善。化學藥物産生的副作用以嘔心，嘔吐及落髮最常見。灌注導管選擇性的置於腹腔動脈或者置於腹主動脈内，其療效對患者的存活時間没有顯著的差異。門靜脈未被腫瘤侵犯者有7人，門靜脈已受腫瘤侵犯者有15人，其平均存活時間分別爲6.8與5.4個月。臨床分期第二期有15人，第三期者有11人。全部26人中22人有追踪檢査，其中5人現仍存活，其存活時間分別爲15，13.5，10，8.5及8個月，全部22人之平均存活時間爲5.8個月。

並列摘要

High prevalence of hepatoma in Chinese community has long been recognized and the prognosis is very poor, no matter whatever the treatment is. From Oct. 1981 to Jan. 1983, 26 proven cases of hepatoma received IAIC with 5-FU, adriamycin and mitomycin-C. Sonography, CT and angiography were performed before treatment and periodically thereafter to evaluate the response of the treatment. In these 26 cases, age ranged from 15 to 74 year-old (average 56.6 year-old), male 24 cases and female 2 cases. Associated with cirrhosis of liver was noted on the pathologic section in 17 cases. The usual side-effect of the chemotherapeutic agent are nausea, vomiting and hair-loss. The course of the treatment was interrupted in 6 cases because of WBC count below 200/ul, 2 cases were associated with platelet count below 75,000/ul. Most of the cases showed symptomatic improvement, especially during the early course of treatment. In 22 cases which have complete followed up, 5 cases remain alive (the follow up time 15, 13.5, 10, 8.5, 8 months). 17 cases were expired with follow-up time ranged from 2 to 10.5 months (mean 4.3 months). Total mean survival time is about 5.8 months.