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多形性神經膠母細胞瘤之放射治療傳統每日一次放射治療與每日多次放射治療之比較

TREATMENT OF GLIOBLASTOMA MULTIFORME: MULTIPLE DAILY FRACTIONATED IRRADIATION VS CONVENTIONAL FRACTIONATED IRRADIATION

摘要


林口長庚紀念醫院放射治療科436例中樞神經系統腫瘤中,有99例是多形性神經膠母細胞瘤,其中34例以每天一次放射治療方式來治療,另外18例以每天多次放射治療來處理,前者需時六週,後者則只需一周時間,經六個月以上之追蹤檢查後,計算其存活率,兩者並沒有差異(Cox's F-lest, P> 0.05),但對存活期短暫之多形性神經膠母細胞適之病患而言,此每日多次放射治療方式值得繼續探討和採用

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並列摘要


Among 436 cases of primary CNS tumor, there are 99 cases of high grade astrocytoma, of which 34 cases were treated with conventional irradiation with equivalent whole brain dose≧4000cGy/20fx/4wks, and also 18 cases were treated with multiple daily fractionated irradiation with dose from 2800cGy/14fx/5days to 3500cGy/ 14fx/5days under high dose steriod coverage. After at least 6 month follow-up, the survivorship among two groups is similar to each other, but the multiple dialy fractionated irradiation group was treated in only one week instead of 6 weeks as with conventional fractionated irradiation.

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