- 期刊
- OpenAccess
Concurrent Radiotherapy and Chemotherapy for Tonsillar Carcinoma: Preliminary Report
同步合併放射線治療與化學治療扁桃腺癌：初期報告
摘要
本研究的目的在分析同步合併放射線治療與化學治療扁桃腺癌的適用性及其初期成果。1990年10月至1997年4月問，12位扁桃腺上皮細胞癌的病患接受同步合併放射線治療與化學治療。平均放射線劑量70Gy,12位病人之同步化學治療包括2次的CDDP與5-FU，放射治療後有6位病人又接受了2次化學治療。進一步記錄分析與治療相關的副作用，局部控制率及存活率。平均追蹤時問28個月後，8位病人維持存活且無疾病復發。沒有病人局部復發，但1位病人發生遠端轉移。兩年局部控制率、無病存活率與整體存活率分別為100%,100%與83%。與治療相關的副作用是中度且可承受的。所有存活病人均保存適當的言語及吞嚥功能。扁桃腺上皮細胞癌的病人可藉由合併放射線治療與化學治療，達到相當理想的疾病控制與功能保存，且副作用是可接受的。此種可以保留外觀及功能的治療方式應有擴大研究其試用之價值。
並列摘要
The purpose of this study is to test the toxicity of concurrent radiotherapy and chemotherapy and evaluate the treatment outcome of the patients with tonsillar carcinoma. From October 1990 to July 1996, 12 patients with squamous cell carcinoma of tonsillar region underwent concurrent radiotherapy and chemotherapy. The median radiation dose was 70 Gy. The regimen of chemotherapy consisted of CDDP and 5.FU for 2 or 4 courses. Treatment-related reactions, local control and survival outcome were recorded and analyzed. With a median follow-up of 28 months (range, 9-67 months ), 8 of 12 patients were still alive without evidence of recurrence. The 2-year local control, disease-free, and overall survival rates were 100%, 100%, and 83%, respectively. One patient developed metastasis to the lung and three others died of unrelated causes. Treatment-related reactions were moderate and tolerable. The speech and swallowing functions were preserved in all surviving patients. Concurrent radiotherapy and chemotherapy is an effective treatment for tonsillar carcinoma. Excellent local control and functional preservation can be achieved with acceptable side effects. The promising and function-preserving treatment justifies a larger trial in the future.
延伸閱讀
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