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Detection of Coronary Artery Calcification by Ultrafast Computed Tomography in Taiwanese

以超快速電腦斷層掃描攝影測定臺灣人之冠狀動脈鈣化

摘要


To provide standard-reference values for screening high-risk asymptomatic subjects in the early detection and management of coronary artery disease (CAD). We used ultrafast computed tomography (UFCT) to detect and quantify coronary artery calcium levels in 138 subjects (mean age 60.2±11.8 year) with (n=49) and without (n=89) CAD. Contiguous 3-mm slices of the coronary arteries were obtained. Total calcium scores were calculated based on the number, area and peak Hounsfield computed tomographic numbers of the detected calcified lesions. The prevalence of coronary calcium in the clinically normal population by different age groups with UFCT was 33% (30-39 years); 55% (40-49 years); 88% (50-59 years); 89% (60-69 years) and 69% (70-80 years). The average total calcium scores for those with versus those without CAD by decade were: 11.5 versus 671.9 (p < 0.0005), age 50 to 59 years; 34.1 versus 768.9 (p < 0.0005), age 60 to 69 years; and 19.6 versus 570.3 (p < 0.001), age 70 to 80 years. There are significantly different values in quantification of coronary artery calcium via UFCT for those with versus without CAD by decades. This data will be used as a reference for screening high-risk asymptomatic subjects.

並列摘要


To provide standard-reference values for screening high-risk asymptomatic subjects in the early detection and management of coronary artery disease (CAD). We used ultrafast computed tomography (UFCT) to detect and quantify coronary artery calcium levels in 138 subjects (mean age 60.2±11.8 year) with (n=49) and without (n=89) CAD. Contiguous 3-mm slices of the coronary arteries were obtained. Total calcium scores were calculated based on the number, area and peak Hounsfield computed tomographic numbers of the detected calcified lesions. The prevalence of coronary calcium in the clinically normal population by different age groups with UFCT was 33% (30-39 years); 55% (40-49 years); 88% (50-59 years); 89% (60-69 years) and 69% (70-80 years). The average total calcium scores for those with versus those without CAD by decade were: 11.5 versus 671.9 (p < 0.0005), age 50 to 59 years; 34.1 versus 768.9 (p < 0.0005), age 60 to 69 years; and 19.6 versus 570.3 (p < 0.001), age 70 to 80 years. There are significantly different values in quantification of coronary artery calcium via UFCT for those with versus without CAD by decades. This data will be used as a reference for screening high-risk asymptomatic subjects.

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