CT Findings of Malignant Gastrointestinal Stromal Tumors with Metastases: An Experience of Cytotoxic Agent and Imatinib Mesylate Treatment

轉移性惡性腸道基質腫瘤電腦斷層的發現：細胞毒性化療劑和Imatinib Mesylate的治療經驗

陳志程(Jyh-Ching Chen) ； 王明宗(Ming-Tsung Wang) ； 錢尚道(Shang-Tao Chien) ； 陳智良(Chih-Liang Chen)

《中華放射線醫學雜誌》 31卷3期 (2006/06) Pp. 149-154

摘要

轉移性腸道基質腫瘤(GIST)是腸道最常見的腫瘤，可以發生於腸道各處。我們報告一個78歲女性患惡性GIST併腹腔轉移。該病患曾接受兩個階段不同的治療。第一階段使用細胞毒性化療劑；第二階段使用而imatinib mesylate （tyrosine活化激醇抑制劑）治療。惡性的GIST有別於其它的腸道間質腫瘤(mesenchymal tumor)。它們通常表現為大的，界限清楚的，不均勻的腫塊，且經常轉移至肝臟，網膜和腹膜腔。CT對GIST的診斷是很有助益的，Imatinib Mesylate對於多數轉移性惡性GIST是有療效的，但對於我們這個病例並無顯著療效。

關鍵字

電腦斷層掃描 ； 腸道基質腫瘤

並列摘要

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors that can occur throughout the gastrointestinal tract. We reported herein the case of a 78-year-old female patient with malignant GIST (M-GIST) with peritoneal metastases, treated in two stages: first with cytotoxic agent and second with imatinib mesylate (a tyrosine kinase inhibitor). M-GISTs are gastrointestinal tumors that differ from other mesenchymal tumors in the gastrointestinal tract in that they usually present large, well-circumscribed, heterogeneous masses, and commonly metastasize to liver, omentum, and the peritoneum, CT scan is helpful in the diagnosis of GISTs. Imatinib mesylate treatment for M-GISTs with metastases is beneficial in the majority of cases, while of limited value in our case.

並列關鍵字

Computed tomography CT ； Gastrointestinal stromal tumor