無機奈米材料在生醫的應用－細胞標定、藥物傳遞及磁振造影

Inorganic Nanomaterials in Biomedical Applications: Cell Targeting, Drug Delivery and Magnetic Resonance Imaging

邱惠琪(Hui-Chi Chiu) ； 葉晨聖(Chen-Sheng Yeh)

《科儀新知》 157期 (2007/04) Pp. 4-9

https://doi.org/10.29662/IT.200704.0001

摘要

無機奈米材料的結構基本上可藉由奈米材料的表面修飾和結構上的特質－中空的內部形成奈米膠囊運用在生醫上。四氧化三鐵奈米粒子(Fe3O4)表面修飾NTA-Ni，藉由與6-His的專一性結合可用於固定生物分子的方向性，並配合RGD4C胜肽對癌細胞上的α(下標 v)β3和α(下標 v)β5有專一選擇性而達到標定癌細胞。奈米棒(β-FeOOH)經高溫(300℃)鍛燒後可得具孔洞性的氧化鐵(β-FeOOH/α-Fe2O3)，依序包覆四層聚合物(PAA/PEI)在其表面使其形成奈米膠囊型態可達到藥物傳遞和保護效果。以奈米空球(Au3Cu1)當磁振造影(MRI)的顯影劑，小鼠的測試結果說明Au3Cu1奈米膠囊可作為正像的顯影劑同時有血管顯影的功用。

並列摘要

Inorganic nanomaterial structures based on surface modification and capsule-like motif can be applied in biomedicine. Fe3O4 nanoparticles modified with nickel-nitrilotriacetate (NTA-Ni) could act as a module to carry 6-His tagged proteins on the surface with molecular orientation control to efficiently target oral cancer cells. The porous nanorods (β-FeOOH/α-Fe2O3) coating with 4 layer polymers (PAA/PEI/PAA/PEI) using layer-by-layer technique formed as nano-capsules to achieve drug release purpose. Au3Cu1 hollow nanoparticles, a new type of MRI contrast agent, showed a promising MR contrast effect.