人腦功能性磁振造影：如何聆聽一齣腦的交響樂

Functional Magnetic Resonance Imaging of Human Brain: How to Listen the Brain Symphony

葉子成(Tzu-Chen Yeh)

《科儀新知》 163期 (2008/04) Pp. 28-34

https://doi.org/10.29662/IT.200804.0004

摘要

從1990年以靜脈注射磁振造影顯影劑的方法，偵測在視覺工作前後的腦血量變化，來標定視覺腦皮質區域，到如今神經放射醫師不需要使用任何顯影劑或藥物，由內在的去氧血紅素、腦血流及腦血量在進行工作時的腦局部變化，提供需要腦部手術之病患的「術前腦圖」，充分展現了非侵入性功能性磁振造影在基礎研究及臨床應用方面的躍進。本文將藉由功能性磁振造影帶您欣賞一齣腦的交響樂，並企圖介紹相關的影像處理介面，希望能增進國內相關的研究或應用。

並列摘要

Through the use of magnetic resonance imaging (MRI) technique the visual cortices were successfully detected in 1990 by measuring the changes of cerebral blood volumes before and after visual stimulations. Over the years, the technique has evolved into a non-invasive technique, called functional MRI (fMRI), in which the contrast comes from regional changes in endogenous deoxy-hemoglobin, cerebral blood flow and/or cerebral blood volume during the stimulation processes. Nowadays, neuro-radiologists often employ the ”pre-surgical brain mapping” by fMRI methods for patients with indications of brain surgery. In this article, an overview of fMRI and the associated image processing interface will be given by introducing the ”performance of a brain symphony”. We hope it can benefit relevant research and applications of local scientists.