應用於慢性疾病的生物自我偵測及回饋誘導藥物釋放系統－以癲癇症為模式

Application of Biological Self-Detection and Response-Induced Features of Drug Delivery System on Chronic Disease: An Empirical Study on Epilepsy

蕭繼聖(Chi-Sheng Hsiao) ； 陳三元(San-Yuan Chen)

《科儀新知》 176期 (2010/06) Pp. 71-77

https://doi.org/10.29662/IT.201006.0009

摘要

本技術主要是要發展一種具有智慧型快速反應的藥物結構釋放系統，此智慧型載體因本身奈米複合結構具有高度的電磁敏感性，可感應來自人體內部由於疾病發作所產生的病理訊號或病徵，例如癲癇症的瞬間放電，經由無線訊號的判讀、偵測及轉換成為電場或磁場誘導之訊號，來刺激或啟動此智慧型奈米複合材料結構及形態的改變，進而釋放出適當藥物劑量，以達到有效疾病預防或治療的效果。

並列摘要

This study investigates the biological self-detection and response-induced features of drug delivery system and its application on chronic disease. Based on an empirical study on epilepsy, this study focuses on the development of an intelligent rapid response drug delivery system. The nanostructured composite of the intelligent carrier in the system is highly sensitive to electromagnetic signals that assimilate to the properties of illness from human body. The instantaneous epileptic discharge can be detected through the signal conversion into electric or magnetic, and these signals will activate the phasic or structural change of the intelligent nanostructured composite to release drugs accordingly. This mechanism is applicable as a therapy for similar chronic diseases.