The association between human papillomaviruses (HPV) and cervical cancer is well established. Up to 99% of all cervical squamous-cell carcinoma harbor HPV DNA. HPV DNA also persists in lymph-node metastases of cervical cancers. It may be hypothesized that HPV DNA molecules reach the regional lymph nodes by the swarming of metastatic tumor cells from the invasive primary. In addition, several studies have demonstrated the presence of HPV DNA in non-metastatic lymph nodes of cervical cancers. It seems also possible that the HPV DNA present to the lymph nodes through the lymphatic drainage system. However, the prognostic significance of HPV DNA in histologically negative nodes remains to be established.