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子宮頸癌淋巴結內人類乳突病毒之檢視

The Prognostic Significance of HPV in Histologically Negative Nodes in Cervical Cancer

摘要


子宮頸癌已確定主由人類乳突病毒(HPV)所引起,高達99%子宮頸鱗狀癌之細胞中會發現HPV DNA。HPV DNA亦存在子宮頸癌轉移之淋巴結中,猜想係由原發部位腫瘤細胞轉移時所帶入,但在沒有轉移腫瘤細胞之淋巴結中,亦存有HPV DNA,病毒應係直接由淋巴系統進入淋巴結,在預後上是否不同,尚待更多的研究。

並列摘要


The association between human papillomaviruses (HPV) and cervical cancer is well established. Up to 99% of all cervical squamous-cell carcinoma harbor HPV DNA. HPV DNA also persists in lymph-node metastases of cervical cancers. It may be hypothesized that HPV DNA molecules reach the regional lymph nodes by the swarming of metastatic tumor cells from the invasive primary. In addition, several studies have demonstrated the presence of HPV DNA in non-metastatic lymph nodes of cervical cancers. It seems also possible that the HPV DNA present to the lymph nodes through the lymphatic drainage system. However, the prognostic significance of HPV DNA in histologically negative nodes remains to be established.

被引用紀錄


辛旻潔(2013)。穿山龍萃取物抑制人類子宮頸癌細胞轉移和侵襲之機制探討〔碩士論文,中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2013.00113

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