- 期刊
以何種Methotrexate方法治療低風險滋養層疾病最佳？
What is the Best Regimen of Methotrexate for Low-Risk Gestational Trophoblastic Disease?
摘要
Methotrexate（MTX）為治療妊娠性滋養層疾病最常使用藥物，特別是在沒有轉移病灶和低危險性患者，單獨使用效果很好，包括：（1）每週注射法；（2）連續5天肌肉注射或靜脈注射法；（3）methotrexate 與folinic acide 隔天注射法，共8天；（4）高劑量methotrexate與folinic acide 連續注射法。雖然對低危險性滋養層疾病最理想的方式仍未確定，但回顧文獻結果，以每2週連續5天methotrexate之方式效果最好，且副作用可被接受。
並列摘要
Patients with nonmetastatic and low-risk metastatic gestational trophoblastic disease should be treated with single-agent methotrexate chemotherapy. Several different chemotherapy protocols have been used, including: (1) weekly intramuscular injection; (2) 5-days intramuscular or intravenous push every other week; (3) methotrexate intramuscular every other day alternating with folinic acid over 8 days with at least a 1-week interval; (4) High dose methotrexate infusion with folinic acid beginning 24 hours after start of methotrexate, repeat every 18 days. The best protocol for treating low-risk trophoblastic disease is uncertain, however, 5-day continuing injection every 2 weeks seems to appear a high effective and well-tolerated treatment in literature review.
延伸閱讀
- 林靜儀、林隆堯（2003）。Methotrexate用於子宮外孕之治療成效－非檢選病人之觀察性研究。中山醫學雜誌，14(1)，119-129。https://doi.org/10.30096/CSMJ.200301.0013
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- Chen, C. C., Lin, J. C., Liu, A. H., Shieh, S. M., Lee, W. C., Shih, Y. W., Chien, W. C., Sun, C. A., Chang, W. T., Chang, C. W., & Chu, C. M. (2020). 運用醫院資訊系統監測ezetimibe加入simvastatin治療高血壓病人的療效、安全性及耐受性. 醫療資訊雜誌, 29(4), 39-52. https://www.airitilibrary.com/Article/Detail?DocID=10213155-202012-202103190014-202103190014-39-52
- Chiu, K. Y. (2012). The role of FoxD3 in gestational trophoblastic disease [master's thesis, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200020123