巴金森氏病的藥物治療

Medical Treatment of Parkinson's Disease

黃文柱(Wen-Juh Hwang)

《Acta Neurologica Taiwanica》 12卷1期 (2003/03) Pp. 43-57

https://doi.org/10.29819/ANT.200303.0008

摘要

巴金森氏病的病因及致病機轉目前仍不清楚。現階段的處置以藥物的症狀治療為主。正確的診斷再加上適切的考量病人的年齡、認知功能、主要臨床症狀、併存的內科及精神科疾病，及功能性殘障程度是治療成功的第一步。依據實證醫學的資料，再加上對病程及各種藥品的特性、副作用及重要交互作用的了解；臨床醫師可以有效的改善大部分症狀，提升患者生活品質及工作能力，並可減低藥品的副作用。在治療的過程，醫師及病人同時扮演重要的角色；兩者均須了解治療的目標及藥物治療的限制，並應有一個合理實在的期待。

關鍵字

巴金森氏病 ； 藥物治療 ； 左多巴及其增強劑 ； 多巴胺促進劑 ； 抗乙醯膽鹼類藥品

並列摘要

The etiology and pathogenesis of Parkinson's disease are still unknown. Symptomatic treatment with dopaminergic and anticholinergic medications remains the mainstay at the present time. A correct clinical diagnosis together with considerations of patient's age, cognitive function, main clinical features, concomitant medical and psychiatric disorders, and functional disability is the key element for successful treatment. Based on the data of evidence-based medicine and the knowledge about the disease course and specific profiles of available medications, physicians can significantly improve the patient's clinical symptoms, life quality and employability without concomitant serious adverse drug reactions. Both the physicians and patients play an important role in the management of Parkinson’s disease. They should understand the goals of treatment and the limitations of medications and have a realistic expectation.

並列關鍵字

Parkinson's disease ； Medical treatment ； Dopaminergic drugs ； Dopamine receptor agonists ； Anticholinergic drugs