Risk Factors for Seizures after First-Time Ischemic Stroke by Magnetic Resonance Imaging

I-Hui Chiang ； Wen-Neng Chang ； Wei-Che Lin ； Yao-Chung Chuang ； Ku-Chou Chang ； Nai-Wen Tsai ； Chia-Wei Liou ； Tzu-Kuan Sun ； Song-Seng Loke ； Chao-Tung Chen ； Chih-Fang Huang ； Wei-Cheng Huang ； Pei-Ming Wang ； Cheng-Hsien Lu

《Acta Neurologica Taiwanica》 19卷1期 (2010/03) Pp. 26-32

https://doi.org/10.29819/ANT.201003.0004

並列摘要

Background: Seizures are important neurological complications of ischemic stroke. There is a need to further clrify the risk factors of seizures following ischemic stroke and predict those who will require treatment.
Methods: One hundred and forty-three (143) first-time ischemic stroke patients were enrolled in this oneyear (2002) retrospective study. Prognostic variables were analyzed based on the Cox's proportional hazards model after a minimum follow-up period of six years.
Results: Seizures occurred in 13 first-time ischemic stroke patients, including acute symptomatic seizures in two (1.4%) and unprovoked seizures in 11 (7.7%). Only one progressed to status epilepticus during hospitalization. After six years of follow-up, the median (inter-quartile range) Glasgow Outcome Scale (GOS) was 3 (3, 4) for patients with seizures and 4 (3, 4) for those without seizures. Regarding seizure control after discharge in the 13 cases, 12 were seizure-free with or without anti-epileptic drugs and one had 1-3 seizures per year. Only the presence of cortical distribution of ischemic infarction (p=0.009, OR=5.549, 95% CI=1.53-20.19) was independently associated with seizures by the Cox's proportional hazards model.
Discussion: The incidence of seizures following first-time ischemic stroke is low and may have delayed manifestation. Cortical distribution of the ischemic infarction is a risk factors for seizures.

並列關鍵字

first-ever ischemic stroke ； risk factors ； seizure