Drug-induced rhinitis is a type of non-allergic rhinitis, referring to a clinical spectrum of the development or exacerbation of rhinitis related to the use of certain medications. Three categories of drug-induced rhinitis have been proposed based on the mechanism of action. These include local inflammatory, neurogenic and idiopathic types. Rhinitis medicamentosa, a form of drug-induced rhinitis, has unique characteristics and is related to inappropriate use of topical decongestants. When possible, the offending medication should be discontinued or substituted in terms of management. Although there are no established treatment recommendations for drug-induced rhinitis other than avoidance, clinical experience suggests that it would be reasonable to initiate use of an intranasal corticosteroid spray to treat symptomatically. The addition of an intranasal antihistamine in combination with use of an intranasal corticosteroid may be considered as step-up therapy if the intranasal corticosteroid alone is not effective.