Prevention of CAPD Catheter Related Infection Peritoneal dialysis has been described as a readily available and simple method for selective filtration of excess water, electrolytes and metabolites. It is reported to promote improved well-being and greater personal freedom than hemodialysis through less life-style changes. Since its development in 1968, the Tenckhoff catheter has become one of the most widely used peritoneal catheters. Although the overall incidence of peritoneal-dialysis-related infection complications has been reduced since the introduction of the Y-set and double bag system, catheter-related infections, exit-site-tunnel infections and peritonitis remain the Achilles heel of peritoneal dialysis. In the past few years, many efforts were made to reduce the incidence of catheter-related infections. Several modifications on the Tenckhoff catheter have been studied by randomized controlled trials. Topical mupirocin, applied at the exit-site as part of regular exit-site care, was also proposed as an effective means to reduce the risk of S. aureus exit-site and tunnel infection. The advances and the controversies concerning the effect on prevention of CAPD Catheter related infection are reviewed and addressed.