- 期刊
Increase in Resting Levels of Superoxide Anion in the Whole Blood of Uremic Patients on Chronic Hemodialysis
並列摘要
Recently, use developed a new method to measure the resting level of superoxide anion in whole blood using an ultrasensitive chemiluminescence analyzer and lucigenin amplification. The advantage of this method is that the assay system can be performed in the absence of leukocyte isolation and stimulant administration. In this study, we applied this method to Inca sure the blood resting levels of superoxide anion in 104 uremic patients on chronic hemodialysis (CHD) and 98 sex-and age-matched healthy controls to clarify the influence of HD on blood levels of superoxide anion. Simultaneously, the plasma levels of copper, zinc superoxide dismutase (Cu、Zn-SOD), glutathion peroxidase (GPX), myeloperoxidase (MPO) and lactoferrin (Lacto-F) were measured. The results showed that the basal blood levels of superoxide anion, Cu, Zn-SOD, and MPO in CHD patients were significantly greater than those of healthy controls. However, there was no difference in the basal plasmal levels of Lacto-F and GPX between CHD patients and healthy controls. One session of HO further increased the blood levels of superoxide anion, MPO, Lacto F and Cu, Zn-SOD but not GPX. These results suggest that the blood levels of superoxide anion are higher in CHD patients and further increase after one session of HD. This mechanism should be studied further.
延伸閱讀
- 馬麗卿、孫嘉玲、謝湘俐（2010）。The Depressive Symptoms and Satisfaction of Quality of Life in Hemodialysis Patients。臺灣腎臟護理學會雜誌，9(1)，1-16。https://www.airitilibrary.com/Article/Detail?DocID=17267404-201006-201006170038-201006170038-1-16
- Lin, J. R., Hwang, J. C., Chen, J. A., & Wang, C. T. (2000). Better Survival in Uremic Patient Who Shifts From CAPD to Hemodialysis than those shift to CAPD From Hemodialysis. Acta Nephrologica, 14(4), 325-325. https://www.airitilibrary.com/Article/Detail?DocID=10131671-200010-14-4-325-325-o
- 童美雅、黃麗真、劉旆辰、林卉姍、蔡淑美（2018）。Improvement of Urea Reduction Ratio in Hemodialysis Patients in a Regional Hospital。臺灣腎臟護理學會雜誌，17(1)，29-44。https://doi.org/10.3966/172674042018031701003
- Yang, S. S., Lin, S. H., Chu, P. L., Wu, S. C., Wu, C. C., Tsai, W. S., & Lin, Y. F. (2002). The Effect of Low-Dose Deferoxamine on Anemia in Iron-Overloaded Hemodialysis Patients. Journal of Medical Sciences, 22(6), 283-288. https://www.airitilibrary.com/Article/Detail?DocID=10114564-200212-201305090027-201305090027-283-288
- Tarakçıoğlu, M., Erbağci, A. B., Usalan, C., Deveci, R., & Kocabas, R. (2003). Acute effect of hemodialysis on serum levels of the proinflammatory cytokines. Mediators of Inflammation, 2003(), 15-19. https://doi.org/10.1080/0962935031000096935