Clinical and Etiologic Study of Viral Conjunctivitis during Six Years, 1974 to 1979, Sapporo, Japan

Koki Aoki ； Michio Kato ； Hideo Ohtsuka ； Hiroshi Tokita ； Naoki Nakazono ； Keizo Ishii

《中華民國眼科醫學會會刊》 19卷 (1980/05) Pp. 12-20

https://doi.org/10.30048/ACTASOS.198005.0002

並列摘要

The epidemics of viral conjunctivitis with two new agents, coxsackievirus A-24 (CA24) and enterovirus type 70 (EV70), occurred first in countries of Southeast and Eastern Asia in beginning of 1970s. For appearance of new agents, we started a collaborative study on the viral conjunctivitis, including EKC-like diseases from 1974 in Sapporo. Etiologic study was performed both with virus isolation from eye swabs and serologic tests with paired sera. A total number of clinical viral conjunctivitis tested was 352 cases, aged 0 to 80, of which about 60% was etiologically diagnosed, and their incidence distributed annually from 14 to 108 cases with seasonal clusters during summer.
Major causative agents were adenoviruses; type 8 virus was detected in every year, types 3 and 4 in clusters in some years and type 19 in a sporadic case. Infections with EV70 (acute hemorrhagic conjunctivitis, AHC) were found in 3 years during the study. In addition, there was a infant case with coxsackievirus A9. It was worthy of our notice that CA24 infection was not only found through the study, but its neutralizing antibody was hardly detected in sera of Japanese healthy people, in spite of recent epidemics of CA24 conjunctivitis in many countries of Southeast Asia.
In general, clinical pictures of EKC were seen with AdV-8 infections, while those of AHC with EV70 infections, though the symptoms and signs of AHC tended recently to be slighter in grade. The infections with other types than type 8 of adenoviruses were variable in clinical pictures. It was especially interesting that the ocular infections with AdV-4 were found at least in 16 cases, including a few cases with clinical EKC, in 1979.
These clinical, virologic and epidemiologic findings will be presented.