Befunolol治療原發性開放性隅角青光眼之療效

Clinical Evaluation of Befunolol in the Treatment of Primary Open Angle Glaucoma

傳堯安(Yao-An Fu)

《中華民國眼科醫學會會刊》 24卷1期 (1985/05) Pp. 270-275

https://doi.org/10.30048/ACTASOS.198505.0048

摘要

於患原發性開放性隅角青光眼88名病患之156隻眼中，給予befunolol點眼劑(0.25%，0.5%，1%)以親其療效及其副作用。在三個月的追踪期裏，降眼壓效果自點藥後一週內開始降壓，其中72/156隻眼(44.5%)靠0.25% befunolol，35/156隻眼(22.4%)靠0.5% befunolol，19/156隻眼(12.1%)靠1% befunolol，14/156隻眼(8.9%)靠其他降壓藥物與1% befunolol合併使用，均獲得良好眼壓控制，降眼壓的幅度隨藥劑濃度增高而上升，若與其他藥物如pilocarpine，acetazolamide合併使用，則更具相成降眼壓的功效。
大約9.0%的病患感覺其副作用，但一般的忍受力均甚良好，尤其如瞳孔縮小，調節性痙孿，結合膜充血等局部症狀均無可見，其他如血壓下降，心跳減慢也無發生，因此befunolol確實為治療原發性開放性隅角青光眼之良藥。

並列摘要

One hundred and fifty-six eyes of 88 patients with primary open angle glaucoma were treated with Befunolol Ophthalmic Solution (0.25%, 0.5%, 1%) and were studied over a mean period of 3 months. Adequate levels of controlled IOP were obtained in 72 of the 156 eyes (44.5%) with 0.25 Befunolol, in 35 of the 156 eyes (22.4%) with 0.5% Befunolol, in 19 of the 156 eyes (12.1%) with 1% Befunolol, and in 14 of the 156 eyes (8.9%) with 1% Befunolol combined with other antihypertensive agents. The pressure lowering effect increased as the concentration increased. Also, Befunolol had the additive effect of further lowering IOP in patients taking Acetazolamide and pilocarpine.
Approximately 8.8% of patients showed side effects. Local signs such as miosis, accomodative spasm and conjunctival hyperemia were not observed. Befunolol had no effect on changes of blood pressure and heart rate. Therefore Bedunolol should be considered as the treatement of choice in open angle glaucoma.

並列關鍵字

primary open angle glaucoma ； intraocular pressure ； side effect