主題瀏覽
- 期刊
- OpenAccess
糖尿病老鼠視網膜多巴胺第一型受器活性的變化
Changes of Dopamine DA-1 Receptor Activities in the Retina of Experimental Diabetic Rats
摘要
為了解糖尿病老鼠視網膜多巴胺第一型受器活性的變化，本篇以不同的方法包括(1)靜脈注射streptozotocin(2)靜脈注射Alloxan及(3)胰臟切除(pancretectong)來引致糖尿病，再比較其視網膜多巴胺第一型受體活性。結果顯示出糖尿病老鼠視網膜第一型受體活性的結合速率有明顯下降，其結果表示在糖尿病老鼠的視網膜在早期的糖尿病高血糖時其視網膜多巴胺第一型受體此有明顯變化。
關鍵字
無資料並列摘要
Alterations of dopamine DA-1 receptor in retina, which may be associated with the development of diabetic retinopathy, were investigated using (1) intravenous injection of streptozotocin, (2) administration of alloxan, and (3) application of pancreatectomy induced hyperglycemic rats. The retina from these diabetic rats was isolated for study of receptor bindings using [3H] SCH 23390 as radioligands. Activity of dopamine DAI receptors was then compared with the control group at the 3rd date of expermintal diabetic rats. The binding affinity (Kd values) of DA-1 binding sites measured with [3H] SCH 23390 in rat retina decreased at the 3rd date of hyperglycemia. These results suggest that retinal dopamine DA-1 receptors were changed at the early stage of acute hyperglycemic rats. The Decrease of binding affinity is depent on hyperglycemia, but not the drug toxicity.
延伸閱讀
- 王依婷（2012）。麩醯胺對於糖尿病合併敗血症小鼠發炎反應及肝臟粒線體功能之影響〔碩士論文，臺北醫學大學〕。華藝線上圖書館。https://doi.org/10.6831/TMU.2012.00045
- 蔡佩靜（2014）。萊克多巴胺對心血管疾病大鼠之急性循環生理研究〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2014.00231
- Chen, Y. L. (2007). 老鼠巨噬細胞中由脂多醣誘發的基因表現之調控 [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2007.00609
- Huang, W. J., Chien, E. J., Yeh, J. Y., Chen, J. J., Chiao, Y. C., Wang, P. S., Chang, F. Y., & Doong, M. L. (2012). The Roles of Dopamine Receptor and Adrenoreceptor on the Inhibition of Gastric Emptying and Intestinal Transit by Amphetamine in Male Rats. The Chinese Journal of Physiology, 55(4), 259-266. https://doi.org/10.4077/CJP.2012.BAA054
- Huang, P. C. (2011). Molecular Mechanisms underlying Adenosine Receptor A2A Subtype in Regulating Spontaneous Activity of the Developing Rat Retina [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2011.10466