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N-Butyl-2-cyanoacrylate對Mycobacterium Chelonae生長之影響及臨床上治療Mycobacterium Chelonae引起角膜炎之經驗
In Vitro Effect of N-Butyl-2-Cyanoacrylate on the Growth of Mycobacterium Chelonae and Its Clinical Application in Mycobacterium Chelonae Keratitis
摘要
In vitro susceptibility of M. chelonae to n-butyl-2-cyanoacrylate (Histoacryl blue) was tested by disk diffusion method on Mueller-Hinton agar. We found that this tissue glue is bacteriostatic to the bacterium and the size of inhibition zone is proportinal to the time glue droplet was on agar plate. Clinically, 9 male patients (mean age 31.7±4.1 years old) who suffered from culture-proven M. chelonae keratitis received n-butyl-2-cyanoacrylate as an adjuctive medical therapy. During an average follow-up period of 4.3 months, 7 cases (77.8%) healed without major complication; with an averaged therapeutic course of 40.9±26.5 days, which was significantly shorter (p＜0.05) than those who were treated with topical amikacin only (N=11, 60.4±28.3 days) It is postulated that n-butyl-2-cyanoacrylate, with short-term inhibition on the growth of M. chelonae by the action of peroxide, and a long term barrier effect on PMN-mediated ocular inflammation and or collagenase, promotes wound healing and can be considered as an adjunctive therapy for the keratitis.
關鍵字
無資料並列摘要
In vitro susceptibility of M. chelonae to n-butyl-2-cyanoacrylate (Histoacryl blue) was tested by disk diffusion method on Mueller-Hinton agar. We found that this tissue glue is bacteriostatic to the bacterium and the size of inhibition zone is proportinal to the time glue droplet was on agar plate. Clinically, 9 male patients (mean age 31.7±4.1 years old) who suffered from culture-proven M. chelonae keratitis received n-butyl-2-cyanoacrylate as an adjuctive medical therapy. During an average follow-up period of 4.3 months, 7 cases (77.8%) healed without major complication; with an averaged therapeutic course of 40.9±26.5 days, which was significantly shorter (p＜0.05) than those who were treated with topical amikacin only (N=11, 60.4±28.3 days) It is postulated that n-butyl-2-cyanoacrylate, with short-term inhibition on the growth of M. chelonae by the action of peroxide, and a long term barrier effect on PMN-mediated ocular inflammation and or collagenase, promotes wound healing and can be considered as an adjunctive therapy for the keratitis.
延伸閱讀
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