Endogenous Cortisol Level in Patients with Central Serous Chorioretinopathy

中心漿液性脈絡膜網膜病變之內因性皮質酯酮變化

許淑娟(Shwu-Jiuan Sheu) ； 吳宗典(Tsung-Tien Wu) ； 莊秋同(Chiu-Tung Chuang) ； 畢勇賢(Youn-Shen Bee)

《中華民國眼科醫學會雜誌》 40卷3期 (2001/09) Pp. 270-274

https://doi.org/10.30048/ACTASOS.200109.0012

摘要

目的：探討內因性皮質酯酮與中心漿液性脈絡膜網膜病變之關聯。
方法：收集9位單側中心漿液性脈絡膜網膜病變病人及年齡性別相對應之單側裂孔性網膜剝離病人及正常人各9位並測定其內因性皮質酯酮值，中心漿液性脈絡膜網膜病變之病人並於二週、四週及十二週重覆檢查。
結果：中心漿液性脈絡膜網膜病變病人之平均血漿皮質酯酮值與正常人無顯著差異(8.70±5.48 VS 10.29±6.07 ug/dl，p=0.844)。但裂孔性網膜剝離病人之平均血漿皮質酯酮值則顯著高於中心漿液性脈絡膜網膜病變病人及正常人(18.36±10.79 VS 8.70±5.48，p=0.013；18.36±10.79 VS 10.29±6.07，p=0.017)。
結論：我們的結果無法支持內因性皮質酯酮與中心漿液性脈絡膜網膜病變之相關性。中心漿液性脈絡膜網膜病變可能涉及包括皮質酯酮等之多種致病機轉。

並列摘要

Purpose: To investigate the relationship between endogenous cortisol levels and central serous chorioretinopathy (CSCR).
Methods: Endogenous plasma cortisol levels was determined in nine patients with acute unilateral CSCR and age and sex matched unilateral rhegmatogenous retinal detachment (RRD) patients and normal control. In CSCR group, the examinations were repeated at two-week, four-week and 12-week follow-up.
Results: The mean value of the 8 am plasma cortisol level in the CSCR group had no significant difference with the mean value in the normal control group (8.70±5.48 ug/dl vs 10.29±6.07 ug/dl, p=0.844). Whereas, the mean value of the 8am plasma cortisol level in the RRD group (18.36±10.79 ug/dl) revealed significantly higher value than those in the CSCR group (p=0.013) and the normal control group (p=0.017).
Conclusions: Our results could not support the relationship of endogenous cortisol with CSCR. CSCR might involve multiple pathway of pathogenesis, including non-cortisol one.

並列關鍵字

Central serous chorioretinopathy CSCR ； cortisol ； endogenous ； rhegmatogenous retinal detachment RRD