Clinico-Pathological Correlation of Idiopathic True Exfoliation of the Lens Capsule

原發性水晶體囊真性層狀剝落之臨床病理表徵

許淑娟(Shwu-Jiuan Sheu) ； 李永誠(Yang-Chen Lee) ； 畢勇賢(Youn-Shen Bee) ； 王志生(Jyh-Seng Wang)

《中華民國眼科醫學會雜誌》 40卷4期 (2001/12) Pp. 501-506

https://doi.org/10.30048/ACTASOS.200112.0003

摘要

目的：原發性水晶體囊真性層狀剝落是水晶體囊表層與深層分離捲向前房的一種疾病。文獻上報告不多，與青光眼之關聯眾說紛紜。本研究的目的在探討此類病例之臨床與病理變化暨與青光眼之關聯性。
方法：以回溯病歷法收集21眼（14例病人）具典型由水晶體前囊延伸出之透明波浪狀薄膜。記錄並分析這些病例之基本資料、過去史、眼部及組織病理檢查所見。
結果：14例平均年齡74.9歲，無任何人有過度輻射曝露或眼外傷之病史。其中七眼送組織病理切片檢查者，皆可見明顯水晶體前囊層狀分裂。此外，兩眼併有慢性隅角閉鎖性青光眼，另一眼則因中心網膜靜脈阻塞續發新生血管性青光眼。
結論：本研究結果推測原發性水晶體囊真性層狀剝落之病例可能長期以來均被忽略。但與青光眼之關聯性並未能作出肯定的結論。

並列摘要

Purpose: Idiopathic true exfoliation of the lens capsule is reported as a rare disorder in which the superficial portion of the lens capsule splits from the deeper layer and extends into the anterior chamber. Its correlation with glaucoma is ambiguous. This study was performed to investigate the clinico-pathological features of patients with idiopathic true exfoliation of the lens capsule and the possible correlation with glaucoma.
Methods: Twenty one eyes (14 patients) with a typical clear wavy membrane arising from the anterior lens capsule were collected retrospectively. Demographic data, past history, ophthalmologic, histopathologic and electron microscopic findings were recorded and analyzed.
Results: The average age was 74.9 years and none of the patients had history of extensive radiation exposure or ocular trauma. The histopathologic study in seven eyes revealed splitting of anterior lens capsule. Chronic angle-closure glaucoma was diagnosed in two eyes and neovascular glaucoma secondary to central retinal vein occlusion in one eye.
Conclusions: Results suggest that the incidence of idiopathic true exfoliation of lens capsule might be under-detected and that the possible correlation with glaucoma was not conclusive in this study.

並列關鍵字

Electronic microscopy ； light microscopy ； glaucoma ； true exfoliation of the lens capsule