Intraoperative Ethanol Treatment in Preventing Recurrence of Limbal Papilloma Refractory to Mitomycin-C

Mitomycin-C治療後復發之角膜輪部乳突瘤以手術中乙醇處理預防復發

盧兆功(Chao-Kung Lu) ； 程羽嬿(Yu-Yen Chen) ； 陳克華(Ko-Hua Chen) ； 許紋銘(Wen-Ming Hsu)

《中華民國眼科醫學會雜誌》 46卷2期 (2007/06) Pp. 183-188

https://doi.org/10.30048/ACTASOS.200706.0015

摘要

目的：報告一例針對經手術切除，電燒灼及局部mitomycin-C點眼治療後復發之角膜輪部乳突瘤使用術中乙醇處理的效果。
方法：病例報告。
結果：一位81歲男性，左眼罹患角膜輪部乳突瘤，腫瘤侵犯角膜。經多次手術切除，電燒灼及術後mitomycin-C點眼治療仍舊復發。第二次復發後，病患接受第三次手術治療，術中使用20%濃度乙醇處理病灶90秒後，將病灶切除。術後追蹤28個月，腫瘤無復發情形，亦無其他併發症。
結論：針對經手術治療，電燒及藥物治療後反覆復發之頑固性角膜或結膜乳突瘤，在切除前使用乙醇處理，可有效預防病灶復發。

並列摘要

Purpose: To describe the effect of intraoperative ethanol in the treatment of recurrent limbal papilloma with corneal extension with poor response to surgical excision, cauterization and topical mitomycin-C (MMC).
Methods: Case report.
Results: We reported an 81-year-old man with recurrent limbal papilloma with corneal extension after repeated surgical excision, cauterization, and postoperative MMC eye drop. After two recurrences, in the third time operation, he was then treated with intraoperative 20% ethanol for 90 seconds followed by surgical excision. No recurrence was observed 28 months postoperatively, and no complication was observed during the follow-up period.
Conclusion: Intra-operative ethanol treatment may be useful in the prevention of recurrence of corneal/conjunctival papilloma refractory to surgical excision, cauterization and post-operative topical MMC.

並列關鍵字

Papilloma ； Ethanol