Recently, Ministry of Health and Welfare (MOHW) has partially released their health databank for the public and researchers to enable value-added applications. The purpose of this study is to designa service model with cloud computing architecture for value-added applications of the health data. Inorder to follow MOHW's regulation principles of No-Data-Outflow and On-Site-Analysis, this study used VPN (virtual private network) access coupling with data encryption and de-identification mechanisms to secure data transmission processes and enhance data privacy. A process for heterogeneous data integration has been designed and a value-added application platform has been established for data analysis and management tasks. The results of this study provide a blueprint of cloud-computing service model for Taiwan's Collaboration Centers for Value-added Applications of Health Data, and has been implemented for projects supported by the Department of Statistics of MOHW.