This paper establishes a numerical method to estimate post-earthquake financial loss of an individual RC building. Through nonlinear analysis and seismic performance evaluation, structural behavior subjected to an earthquake excitation can be estimated. Corresponding damage degrees can be determined accordingly. Financial loss in terms of the repair to replacement cost ratio of the most severely damaged storey is estimated based on the post-earthquake damage degree. As a result, the repair cost is obtained and it is clear whether the building needs rehabilitation or rebuilt after demolition. Finally, we take an old building and a lately designed building as examples to establish correlation curves between the spectral displacement and the repair to replacement cost ratio of the most severely damaged storey through nonlinear static pushover analyses. The method proposed in this paper helps decision-making of lifecycle maintenance and management of existing buildings. It also provides a method to control post-earthquake damage consequence and risk for the next-generation of performance-based seismic design.