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  • 期刊

Simultaneous Quantitation of Caffeine, Ethoxybenzamide and Propyphenazone in Oral Analgesic Tablets by High-Pressure Liquid Chromatography

高壓液相層析法定量口服鎮痛錠劑成分咖啡(生僉)、乙氧基苄醯胺及異丙安替比林

摘要


本報告敘述以柳醯胺(salicylamide)為內部標準,利用高壓液相層析法,以μ bondapak C18層析柱及甲醇-乙腈-3%醋酸(24:16:60)為移動相,進行市售口服鎮痛錠劑成分咖啡鹼(caffeine),乙氧基苄醯胺(ethoxybenzamide)及異丙安替比林(propyphenazone)之定量分析。研究顯示本法為一簡單,快速且準確的方法。

關鍵字

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並列摘要


A method for simultaneous quantitation of caffeine, ethoxybenzamide and propyphenazone is described. The method was based on reversed-phase high-pressure liquid chromatography with a mobile phase of methanol-acetonitrile-3% aqueous acetic acid solution (24:16:60, v/v). The compounds were well separated from each other by the propcedure, using salicylamide as internal standard. The method gave excellent results and provided a simple, rapid and accurate method for separation and quantitation of synthetic mixtures and commercial products.

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