- 期刊
Identification, Synthesis and Spectral Characterization of a Potential Impurity of Ceftazidime
並列摘要
During the process development of ceftazidime, a new impurity which exceeded the limit of 0.1% was detected by a simple HPLC method. The molecular weight of the target impurity was determined by LC/MS. This suspected impurity was synthesized and purified for characterization. When co-injected with ceftazidime in HPLC, the retention time of the impurity was the same as the ceftazidime sample containing the impurity. The structural determination of the suspected impurity was conducted by IR, MS, 1H-NMR and 13C-NMR spectroscopic techniques. This new impurity was the methyl ester of ceftazidime, and its structure was determined as (6R, 7R)-7-[[(Z)-2-(2-aminothiazol-4-yl)-2-[(1-methoxycarbonyl-1-methylethoxy) imino]acetyl]amino]-8-oxo-3-[(1-pyridinio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, with molecular formula of C23H24N6O7S2 and molecular weight of 560 Da.
延伸閱讀
- 張彥誠、戴火木（2000）。The Application of Cyclopentadiene and Methylcyclopentadiene in Natural Product Synthesis。化學，58(3)，431-445。https://doi.org/10.6623/chem.2000045
- Chen, M. Y. (2015). Synthesis and Catalytic Studies of Hierarchical MFI Zeolite Materials [master's thesis, National Tsing Hua University]. Airiti Library. https://doi.org/10.6843/NTHU.2015.00105
- 蘇冠宇（2015）。Studies on the Development of A Facile and Efficient Method for Per-O-Acetylation of Carbohydrates by Iodine Monochloride〔碩士論文，中原大學〕。華藝線上圖書館。https://doi.org/10.6840/cycu201500942
- 王怡惠（2013）。Synthesis and Characterization of Triazine-based Polyureas〔碩士論文，國立暨南國際大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0020-3108201315490000
- Lee, J. F. (2012). Synthesis, Characterization and Photophysical Properties of Aryl-Imidazophenanthrolines [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2012.00353