Effects of Ma-Xing-Shi-Gan-Tang on Bleomycin-Induced Lung Fibrosis in Rats

麻杏甘石湯對實驗性肺纖維化的干預治療作用

張振偉(Chen-Wei Chang) ； 林志展(Chih-Chan Lin) ； 連小茵(Hsiao-Yin Lien) ； 林水昌(Yung-Chang Lin) ； 陳永軒(Yung-Husan Chen) ； 張芳榮(Fang-Rong Chang) ； 李振華(Zhen-Hua Li)

《藥物食品分析》 19卷2期 (2011/06) Pp. 139-145

摘要

在本研究中，利用博萊霉素(bleomycin)誘發大鼠肺部纖維化實驗，大鼠每天口服傳統中藥複方麻杏甘石湯(Ma-Xing-Gan-Shi-Tang; MXGST; 1g/kg)，其肺泡發炎細胞量有明顯的改善，此結果推測麻杏甘石湯對於肺部細胞膜的損害可能有改善的效果，在博萊霉素誘發肺部纖維化實驗組，發現一氧化氮(NO)含量有明顯的增加，在麻杏甘石湯治療後，則有顯著性的下降。MXSGT亦能防止superoxide dismutase (SOD)的耗盡，並且降低myeloperoxidase (MPO)活性和malondialdehyde (MDA)在纖維化肺組織之含量。由實驗的結果推測，麻杏甘石湯中具抗肺纖維化的抗氧化物可抑制一氧化氯的生成，並有效參與了bleomycin在大鼠誘發肺纖維化疾病之機轉。

關鍵字

特發性肺間質纖維化 ； 博萊霉素 ； 麻杏甘石湯 ； 一氧化氮

並列摘要

In this study, after doses of 1 g/kg/day of the traditional Chinese formula Ma-Xing-Shi-Gan-Tang (MXSGT), significant reversal of pneumatocysts was achieved in Spague-Dawley rats with bleomycin-induced lung fibrosis. We found that MXSGT can improve the damaged condition of general cellular membranes. Greatly increased levels of lung NO were found in the bleomycin-induced group, which were then significantly reduced by MXSGT. MXSGT drastically prevented depletion of superoxide disinutase (SOD) and reduced the myeloperoxidase (MPO) activities and malondialdehyde (MDA) levels in lung tissue of rats treated svith bleomycin. On the basis of the results presented in this paper. MXSGT prevents bleomycin-induced lung fibrosis, and the mechanism may be due to the inhibitory effect on nitric oxide generation in the bleomycin-induced lung-fibrosis model of rats.

並列關鍵字

Idiopathic pulmonary fibrosis ； bleomycin ； Ma-Xing-Gan-Shi-Tang ； nitric oxide