Radix Aconiti kusnezoffii Exhibits an Antinociceptive Activity Involvement at Central and Peripheral Nervous System

草烏在中樞及周邊神經系統上之鎮痛活性成效

賴美州(Mei-Chou Lai) ； 劉怡旻(I-Min Liu) ； 劉崇喜(Shorong-Shii Liou) ； 張永勳(Yuan-Shiun Chang)

《藥物食品分析》 20卷2期 (2012/06) Pp. 501-509

https://doi.org/10.6227/jfda.2012200211

並列摘要

The dry root of Aconiti kusnezoffii, also named Cao Wu, is widely used as folk medicine in China to treat rheumatic pain, paralysis due to stroke, carbuncle, and furuncle. In the present study we investigated the molecular mechanisms of its analgesic and anti-inflammatory activities. Using the acetic acid-induced writhing and formalin test models in mice, our results clearly showed that the constituents of processed Radix Aconiti Kusnezoffii can reduce both peripherally and centrally induced pain in a dose-dependent manner. Mice treated with processed Radix Aconiti Kusnezoffii has significantly increased levels of glutathione peroxidase, glutathione reductase, and superoxide dismutase activities in the liver compared to untreated controls. Furthermore, treated mice exhibited lower levels of malondialdehyde after carrageenan injection compared to untreated controls. In conclusion, our results demonstrate that the ingredients in the processed Radix Aconiti Kusnezoffii can effectively reduce pain involving in the peripheral and central nervous systems and exhibit anti-inflammatory activity. The pharmacological analgesic and anti-inflammatory properties of Radix Aconiti Kusnezoffii may be attributed to the elevation of hepatic anti-oxidative enzymes to eradicate free radicals.

並列關鍵字

Antinociceptive activity ； Anti-inflammatory activity ； Radix Aconiti Kusnezoffii (Cao Wu)

參考文獻

Bisset, N. G. 1981. Arrow poisons in China. Part II: Aconitum-botany, chemistry, and pharmacology. J. Ethnopharmacol. 4 : 247-336.

Xu, H., Arita, H., Hayashida, M., Zhang, L., Sekiyama, H. and Hanaka, K. 2006. Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats. J. Ethnopharmacol. 103: 392-397.

Tu, Y., Yang, P., Sun, S. Q., Zhou, Q., Bao, X. H. and Isao, N. 2010. Analysis of fingerprints features of infrared spectra of various processed products of Radix Aconiti Kusnezoffii . J. Mol. Struct. 974: 103-107.

Yamada, K., Suzuki, E., Nakaki, T., Watanabe, S. and Kanba, S. 2005. Aconiti tuber increases plasma nitrite and nitrate levels in humans. J. Ethnopharmacol. 96: 165-169.

Vane, J. R. and Botting R. M. 1995. New insights into the mode of action of anti-inflammatory drugs. Inflamm. Res. 44: 1-10.