Multi-Residue Determination of Sulfonamide and QuinoloneResidues in Fish Tissues by High Performance LiquidChromatography-Tandem Mass Spectrometry (LC-MS/MS)

A LC-MS/MS method was validated for the simultaneous quantification of 4 quinolones (oxolinic acid, enrofloxacine, ciprofloxacine, norfloxacine) and 4 sulfonamides (sulfamethoxypyridazine, sulfadoxine, sulfadimidine, sulfamerazine) on fish muscle following the European Union's (EU) criteria for the analysis of veterinary drug residues in foods. One gram of sample was extracted by acidic acetonitrile (0.5 mL of 0.1% formic acid in 7 mL of ACN), followed by LC-MS/MS analysis using an electrospray ionization interface. Typical recoveries of the 4 quinolones in the fish tissues ranged from 85 to 104%. While those of the sulfonamides ranged from 75 to 94% at the fortification level of 5.0 μg/kg. The decision limits (CCα) and detection capabilities (CCβ) of the quinolones were 1.35 to 2. 10 μg/kg and 1.67 to 2.75 μg/kg, respectively. Meanwhile, the CCα and CCß of the sulfonamides ranged from 1.62 μg/kg to 2.53μg/kg and 2.01 μg/kg to 3.13 μg/kg, respectively.

並列關鍵字

quinolones ； sulfonamides ； LC-MS/MS ； matrix effect

參考文獻

Stolker, A. A. M. and Brinkman, U. A. Th. 2005. Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals-a review. J. Chromatogr. A 1067: 15-53.

Wolfson, J. S., Hooper, D. C. and Swartz, M. N. 1989. Isolation and characterization of an Escherichia coli strain exhibiting partial tolerance to quinolones. Antimicrob. agents chemother. 33: 705-709.

Hustvedt, S. O., Salte, R. and Vassvik, V. 1992. Combatting cold-water vibriosis in Atlantic salmon (Salmo salar L.) with oxolinic acid: A case report. Aquaculture 103: 213-219.

Samuelsen, O. B. and Bergh, O. 2004. Efficacy of orally administered florfenicol and oxolinic acid for the treatment of vibriosis in cod (Gadus morhua). Aquaculture 235: 27-35.

Toussaint, B., Bordin, G., Janosi, A. and Rodriguez, A. R. 2002. Validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of 11 (fluoro) quinolone antimicrobials in swine kidney. J. Chromatogr. A 976: 195-206.

被引用紀錄

Huang, T. T. (2011). 探討resveratrol和osajin對鼻咽癌之抗腫瘤作用及機制 [doctoral dissertation, National Central University]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0031-1903201314412194

延伸閱讀

Chang, C. S., Wang, W. H., & Tsai, C. E. (2010). Simultaneous Determination of 18 Quinolone Residues in Marine and Livestock Products by Liquid Chromatography/Tandem Mass Spectrometry. 藥物食品分析, 18(2), 87-97. https://www.airitilibrary.com/Article/Detail?DocID=10219498-201004-201005280004-201005280004-87-97
Zhou, X. C., Cheng, Z., Ran, L. L., Guo, X., Liu, Z., & Yu, P. (2011). Determination of Glucosamine in Human Plasma by High-Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionization Source-TandemMass Spectrometry. Chromatography Research International, 2011(), 120-126. https://doi.org/10.4061/2011/815183
Hung, W. H. (2018). Determination of Diethyl Phthalate and Personal Care Products in Fish Tissues with Ultra-performance Liquid Chromatography/tandem Mass Spectrometry [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU201802422
Chang, C. S., Wang, W. H., & Tsai, C. E. (2008). Simultaneous Determination of Eleven Quinolones Antibacterial Residues in Marine Products and Animal Tissues by Liquid Chromatography with Fluorescence Detection. 藥物食品分析, 16(6), 87-96. https://www.airitilibrary.com/Article/Detail?DocID=10219498-200812-16-6-87-96-a
李免蓮、鄧名志、徐阿里（2008）。Determination of five sulfonamide residues in feed and milk by liquid chromatography tandem mass spectrometry with solid phase extraction。畜產研究，41(4)，307-317。https://www.airitilibrary.com/Article/Detail?DocID=P20200930001-200812-202011110014-202011110014-307-317

國際替代計量

Multi-Residue Determination of Sulfonamide and QuinoloneResidues in Fish Tissues by High Performance LiquidChromatography-Tandem Mass Spectrometry (LC-MS/MS)

全文下載

主題瀏覽