Focusing on marble and serpentinite, this study aims to investigate the variation of generally physical indices, microstructure, and mechanical properties of the rocks under man-made dried-wetted-cycling process. Experimental results reveal that the calcite mineral of marble dissolves during artificial weathering cycles and leads to descending of grain contact degrees. Intact rock strength and deformability of marble reduces as cycling number increases, but the variation of weathering resistance increases. For serpentinite, mineral dissolution and phase transition are observed during artificial weathering. Mineral dissolution results in rock softening of the rock. However the quartz formed from phase transition is helpful for the bonding between grain contacts. During cycling process both the weathering resistance and mechanical properties have insignificant period and limited increasing trends.