In the design of weldments, only considering the fatigue strength, ultimate stress and yield stress of materials to design is not a complete work. The effects of the welded joint composition on the fatigue life need to be considered for guaranteeing the quality and safety of weldments. In the experimental investigations into the fatigue life of the butt-welded joints, all ASTM A36 specimens including unmilled weldment, milled weldment and unwelded structure were used for fatigue tests at several constant loading levels at frequency 20 Hz and at the stress ratio R=0.1. The fatigue damage of three different specimens were analyzed from macroscopic and microscopic observation of the fracture surface. Furthermore, the prediction model of fatigue life for welded joints was discussed from the experimental statistics results.