The optimum process mean setting is an important method of modern statistical process control for determining the quality level. In 1994, Al-Sultan presented a single sampling plan applied in determining the optimum process mean for two machines in a serial production system. However, he didn’t consider the quality cost for the product within the specification limits, pointed out that the non-conforming items in the sample of accepted lot is replaced or eliminated from the lot, and proposed an integrated model with production and quality. In this paper, the author proposes a modified economic manufacturing quantity (EMQ) model based on a modified Al-Sultan’s model with k machines in a serial production system and asymmetric quadratic quality loss function for obtaining the maximum expected total profit per unit of time.