The evacuation planning of the nuclear disaster incident is different with the evacuation planning of general natural disasters. Nuclear disasters will produce radiation dust pollution area. It is important to decontaminate the radiant dust before evacuating from the radiation contaminated area. Therefore, there are two issues in the evacuation problem of nuclear disasters. Firstly, how to choose the decontaminate radiation dust position for the victims in the evacuation of the task. Secondly, choose the optimal evacuation route for the victims. Nonlinear programming is used to formulate an evacuation route planning model for nuclear disaster incident in this study. The optimality conditions also have been proof. We also developed a solution algorithm to solve the problem. After numerical example tests, The optimal decontaminate radiation dust position choice and evacuation route choice can be obtained simultaneously from the proposed model. When it comes to the nuclear disaster incident, the study is advantage to support the decision-making for the evacuation planning.