Quantitative Liver-Spleen Scintigraphy for the Assessment of Diffuse Liver Diseaes

定量肝脾閃爍攝影應用於瀰漫性肝臟疾病之評估

劉豐源(Feng-Yuan Liu) ； 錢本文(Poon-Ung Chieng) ； 顏若芳(Ruoh-Fang Yen) ； 蘇誠道(Cheng-Tau Su)

《核子醫學雜誌》 12卷4期 (1999/12) Pp. 181-187

摘要

前言：肝脾閃爍攝影可用來偵測瀰漫性肝臟疾病的存在，然而依視覺來判斷平面影像容易產生誤差，使用量化之參數以及單光子射出斷層造影是較爲客觀正確的方法。方法：利用全身的菲汀酸鹽肝脾閃爍攝影以及單光子射出斷層造影，我們提出一個新方法來計算肝臟與脾臟對菲汀酸鹽的攝取比率，我們並對十三位病人作了攝影及分析。結果：對於這十三位病人，肝臟對菲汀酸鹽的攝取比率介於26.4％與76.9％之間，而脾臟對菲汀酸鹽的攝取比率介於3.2％與43.0％之間。肝臟對菲汀酸鹽的攝取比率與Hoefs所發展並經許多研究用來代表肝臟功能存量的參數有非常高的相關性。結論：全身性肝臟對菲汀酸鹽的攝取比率與Hoefs所發展的參數有非常高的相關性，因此其與瀰漫性肝臟疾病的嚴重程度亦應有密切的相關。

關鍵字

肝脾閃爍攝影 ； 菲汀酸鹽(phytate) ； 瀰漫性肝臟疾病 ； 單光子射出斷層造影

並列摘要

Introduction: Radionuclide liver-spleen scintigraphy has been used to identify diffuse hepatic disease. Since the visual interpretation of planar images is prone to imprecision, quantitative parameters using SPECT are more objective and accurate. Methods: We proposed a method for the estimation of whole body phytate uptake ratios of the liver and spleen using whole body liver-spleen scan and regional SPECT. Thirteen patients were assessed with our method and Hoefs' semiquantitative parameters. Results: In these thirteen patients, the phytate uptake ratio of the liver ranged from 26.4% to 76.9%,and that of the spleen ranged from 3.2% to 43.0%.The phytate uptake ratio of the liver correlated very well with the Hoefs' parameters that had been studied extensively to represent hepatic functional reserve. Conclusion: Whole body phytate uptake ratio of the liver which is calculated by our method correlates very well with Hoefs' parameters and should be closely correlated with the severity of diffuse liver disease.

並列關鍵字

liver-spleen scintigraphy ； phytate ； diffuse liver diseaes ； SPECT