The Role of 99mTc-HMPAO Lung Image in Evaluation of Pulmonary Involvement in Systemic Lupus Erythematosus Patients with Negative Chest X-Ray: A Preliminary Study

鎝—99m—HMPAO肺部造影對于評估懷疑有肺部影響但正常胸部X光影像的系統性紅斑狼瘡病人的可用性：先期研究

孫盛生(Shung-Shung Sun) ； 莊豐如(Feng-Ju Chung) ； 高嘉鴻(Chia-Hung Kao)

《核子醫學雜誌》 16卷1期 (2003/03) Pp. 21-24

https://doi.org/10.6332/ANMS.1601.004

摘要

背景：造成系统性紅斑狼瘡的病因仍是未知，而肺部功能受到影響可能是造成致病率和致死率的顯著因素。本研究之目的在於評估是否能以鎝-99m-HMPAO肺部造影來評估懷疑有肺部影響但胸部X光影像卻正常的系統性紅斑狼瘡病人的可用性。方法：懷疑有痴呆症或中風發作而做鎝-99m-HMPAO腦部血流造影的25位病人和20位患有系統性紅斑狼瘡的病人，其中10位系统性紅斑狼瘡病人有明顯肺部症状的表現：然而所有病人的胸部X光皆爲正常。在注射20-25mCi鎝-99m-HMPAO 10分鐘後，實行包含大部份肝臟的胸腔前位攝影。肝臟和肺臟的目標區域(ROI)值將被計算。結果：非系統性紅斑狼瘡病人之肺臟／肝臟吸收比值之平均值爲0.36±0.1：而系統性紅斑狼瘡病人則爲0.79±0.58。系統性紅斑狼瘡病人之肺臟／肝臟吸收比值明顯較高。結論：本研究發現鎝-99m-HMPAO肺臟/肝臟吸收比值對於評估正常胸部X光影像但懷疑有肺部影響的系统性紅斑狼瘡病人可能是一個很有用的工具，然而需要更多的研究及追蹤來確認。

關鍵字

鎝—99m—HMPAO ； 系統性紅斑狼瘡 ； X光

並列摘要

Backgrounds: Systemic lupus erythematosus (SLE) is
a disease of unknown etiology characterized by the
presence of multiple autoantibodies and immunologically
mediated tissue damage. Pulmonary involvement in
SLE may be a significant cause of morbidity and mortality.
The aim of this study was to assess the clinical
role of 99mTc-HMAPO lung image in the evaluation of
pulmonary involvement in SLE patients with negative
chest X-ray findings.
Methods: Twenty-five patients without SLE who were
referred for brain imaging studies for dementias or
strokes and 20 patients with SLE underwent this investigation.
Of the 20 SLE patients, 10 had significant clinical
pulmonary manifestations. All SLE patients had normal
chest X-ray findings. Anterior lung image including
a large part of the liver was taken 10 minutes after
intravenous injection of 20-25 mCi of 99mTc-HMAPO.
Regions-of-interest (ROIs) over the liver and lung were
calculated.
Results: The mean lung-to-liver uptake ratio in patients
without SLE was 0.36±0.1; the mean lung-to-liver
uptake ratio in SLE patients was 0.79±0.58. The lungto-
liver uptake ratios of SLE patients were significantly
higher than those of patients without SLE.
Conclusion: Our results indicate that the ratio of lungto-
liver uptake of 99mTc-HMAPO may be a useful complementary
method to assess pulmonary involvement in
SLE patients with negative chest X-ray findings.
However, a larger series of SLE patients and long-term
follow-up study are necessary to confirm our findings.

並列關鍵字

99mTc-HMAPO ； systemic lupus erythemato-sus ； X-ray