The Effect of Pentoxifylline in Improving Tumor Hypoxia Assessed by (superscript 99m)Tc-HL91-NI

以鎝－99m-HL91-NI評估Pentoxifylline改善腫瘤缺氧的效果

洪光威(Guang-Uei Hung) ； 李慧楨(Huei-Jane Lee) ； 夏建忠(Chien-Chung Hsia) ； 李永康(Jong-Kang Lee)

《核子醫學雜誌》 21卷4期 (2008/12) Pp. 217-222

https://doi.org/10.6332/ANMS.2104.004

摘要

目的：鎝-99m-HL91-NI是由核能研究所研發的一種全新缺氧造影劑。而pentoxifylline(PTX)則是一個周邊血管的擴張藥物，已被發現可以改善腫瘤缺氧並促進放射線治療的效果。本研究之目的是在評估以鎝-99m-HL91-NI偵測PTX改善有瘤缺氧效果的可行性。
方法：首先建立移植MDA-MB-231人類乳癌細胞的裸鼠動物模型，實驗組裸鼠預先施予100毫克PTX，沒有PTX給藥的裸鼠作爲對照組。鎝-99m-HL91-NI注射後2小時進行全身掃描，並計算腫瘤－背景的攝取比值(T/B ratio)。
結果：不論實驗組或對照組，鎝-99m-HL91-NI在腫瘤上均呈現較高的吸收。此外，對照組的腫瘤攝取鎝-99m-HL91-NI明顯比實驗組高。對照組與實驗組的平均T/B比值分別是3.53±0.55和1.95±0.34(P=0.01)。
結論：初步的研究結果顯示核研所製備的鎝-99m-HL91-NI可以非侵犯性地在活體上評估PTX改善腫瘤缺氧的效果。在進行臨床應用之前，則需有更進一步的人體試驗資料來支持。

關鍵字

鎝－99m-HL91-NI ； 腫瘤 ； 缺氧 ； pentoxifylline

並列摘要

Purpose: (superscript 99m)Tc-HL-NI is a novel hypoxia-imaging agent synthesized by the Institute of Nuclear Energy Research (INER). Pentoxifylline (PTX) is a peripheral vasodilator and has been found to improve tumor hypoxia and to enhance response to radiotherapy. The purpose of the study was to evaluate the feasibility of using (superscript 99m)Tc-HL91-NI for assessing the effect of PTX in modifying tumor hypoxia.
Methods: The human breast cancer-bearing nude mice were pretreated with 100 mg of PTX as the study group. (superscript 99m)Tc-HL91-NI was administered intravenously and whole body scan was performed at 2 h post-injection. The uptake ratios of tumor-to-background (T/B) were measured. Parallel studies without PTX pretreatment were performed as control group for comparison.
Results: There was relatively higher uptake of (superscript 99m)Tc-HL91-NI in tumor compared to the contralateral thigh. In addition, the tumor uptake of (superscript 99m)Tc-HL91-NI was significantly reduced in PTX treated group than controls. The T/B ratios of (superscript 99m)Tc-HL91-NI were 1.95±0.34 and 3.53±0.55 for PTX and control groups, respectively (P=0.01).
Conclusions: The preliminary results suggested that (superscript 99m)Tc-HL91-NI prepared by INER could be used to noninvasively evaluate the effect of PTX in improving tumor hypoxia in vivo. Further human trials should be warranted before its clinical applications.

並列關鍵字

(superscript 99m)Tc-HL91-NI ； tumor ； hypoxia ； pentoxifylline