- 期刊
The Neuroleptic Malignant Syndrome and Acute Renal Failure
抗精神病藥物惡性症候群與急性腎衰竭
摘要
抗精神病藥物惡性症候群是一種在服用抗精神病藥物期間或停用多巴胺性(dopaminergic)藥物時，發生肌肉彊直，神志改變及體溫上升的疾病。橫紋肌溶解症是一種骨骼肌受損所表現的現象。許多因橫紋肌溶解症造成肌蛋白性腎衰竭在臨床上只呈現有血中肌酐酸基酶(creatine phosphokinase, CPK)上升的現象。本文描迷一個抗精神病藥物惡性症候群病患因橫紋肌溶解症導致了腎衰竭，同時詳述了抗精神病藥物惡性症候群的臨床診斷、鑑別診斷、病理機轉。我們同時討論了抗精神病藥物惡性症候群與腎衰竭間的關係，以及各種治療方法。
並列摘要
Neuroleptic malignant syndrome is characterized by the development of muscle rigidity, altered consciousness and hyperthermia during the administration of neuroleptics or the withdrawal of dopaminergic agents. Rhabdomyolysis is a clinical phenomenon arising from skeletal muscle injury. Many patients suffering from myoglobinuric renal failure present with asymptomatic rhabdomyolysis from elevations in serum creatine phosphokinase (CPK). In this article, we review a case of drug-induced rhabdomyolysis with renal failure in a patient with the neuroleptic malignant syndrome (NMS). We address the significant clinical features of NMS, the spectrum of differential diagnosis and its pathophysiology. The association between NMS and renal failure and various therapies for this potentially fatal drug reaction are discussed.
延伸閱讀
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