Rapid Occurrence of QT Prolongation and Torsades de Pointes after Combined Administration of Itraconazole and Terfenadine

Torsades de pointes是一具有生命危險的心室不整脈，可由先天或後天的病因所引起。本病例是一80歲女性，因患灰指甲服用itraconazole已有2月，在合併使用terfenadine短短27小時後，即發生QT延長及torsades de Pointes。此併發症可歸因於藥物交互作用及terfenadine過量。因此，在使用這類藥物前，應詳細詢問病史，避免合併使用此二藥物。

關鍵字

terfenadlne ； torsades de pointes

並列摘要

Torsades de pointes, a potentially life-threatening polymorphic ventricular arrhythmia, can occur with a variety of congerital and acquired conditions. An 80 year-old female who had been receiving itraconazole for 2 months for onycomycosis developed QT prolongation and torsades de pointes 27 hours after the coadministration of terfenadine. The rapid onset of this complication may be due to the combined effects of drug interaction and terfenadine overdose. A detailed history should be taken before prescribing either drug and their combination should be avoided.

並列關鍵字

terfenadine ； torsades de pointes

國際替代計量

Rapid Occurrence of QT Prolongation and Torsades de Pointes after Combined Administration of Itraconazole and Terfenadine

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