摘要
抗精神病藥物惡性症候群是一種因為使用抗精神病藥物所引起的罕見、與具有潛在致命性急症。抗精神病藥物惡性症候群會引起意識改變、高燒、「鉛管樣」肌肉僵直併橫紋肌溶解症。本文將回顧此病的發生率與死亡率、臨床表徵、診斷與鑑別診斷、病理機轉、誘發與加重因素、病程、治療、併委症與預後。雖然，抗精神病藥物惡性症候群尚未完全了解，但對於本病仍需儘早診斷、儘早治療以降低其死亡率。
並列摘要
Neuroleptics malignant syndrome is a rare, emergent and potentially lethal complication of antipsychotics therapy. Neuroleptic malignant syndrome presenting features include: fever, altered level of consciousness, and ”lead-pipe” skeletal muscle rigidity causing rhabdomyolysis. In this article, the author reviewed the incidence, mortality rate, clinical manifestations, diagnosis, differential diagnosis, pathophysiology, risk and contributing factors, course of illness, treatment, complications and progression. Although NMS remains not well understood, early recognition and treatment are very important to decrease the mortality rate.
延伸閱讀
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- 林承昌、林志強、諶立中（2006）。非典型症狀抗精神病藥物惡性症候群－病例報告。台灣家庭醫學雜誌，16(2)，134-141。https://doi.org/10.7023/TJFM.200606.0134
- 宋承岳、呂宜蓉、林光勳、洪景明、黃瓊芳（2010）。非典型性抗精神病藥物惡性症候群－病例報告。中華民國家庭牙醫學雜誌，5(3)，24-29。https://doi.org/10.6566/JFD/2010.5(3).24
- Bandarchi, B., Ma, L., Navab, R., Seth, A., & Rasty, G. (2010). From Melanocyte to Metastatic Malignant Melanoma. Dermatology Research and Practice, 2010(), 235-242. https://doi.org/10.1155/2010/583748