並列摘要
Ethylene glycol ethers (EGE) are a group of solvents with widely use in many industries, such as painting, inking, glueing and dyeing. They could be absorbed through digestion tract, respiratiory tract and skin. There were many studies demonstrated that the metabolites of EGE could induce fertility (azoospermia), hematologic toxicity (anemia), encephalopathy and teratogensis. Furthermore, the long half-life of the metabolites could cause their accumulation and induce apparent injuries of target organs. The genetoxicity and carcinogencity of EGE are still controversial and the pathogenesis of EGE that induce genetic injury is still not clear. The present article reviewed some studies to discuss the genetoxicity of EGE. However, further large scale and follow-up studies in the genetoxicity of EGE are necessary.
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