乙二醇中毒

Ethylene Glycol Intoxication

郭建偉(Giian-Wei Gao) ； 林裕峰(Yuh-Feng Lin) ； 林石化(Shin-Hua Lin) ； 謝善德(Shang-Der Shieh)

《中華職業醫學雜誌》 2卷3期 (1995/07) Pp. 131-137

摘要

乙二醇為一工業極重要且普遍的化學原料，死亡率並非由於本身之毒性，而在於其酒精去氫酵素代謝之後的終產物，甲酸及草酸為最重要的毒性產物。除了詳細詢問病史外，快速診斷根基於出現陰離子及滲透壓間隙；同時於尿液顯微鏡檢中可看到針狀或信封狀的草酸鈣結晶。因酒精可以有效地競爭酒精去氫酵素以進一步阻斷有毒終產物的產生，所以它可以提供病人極佳的預後，因此快速診斷及早期酒精治療是處理乙二醇中毒最重要的步驟。

關鍵字

乙二醇 ； 乙醇 ； 陰離子 ； 滲透壓間隙

並列摘要

Ethylene glycol is an important and common industrical chemical. The mortality of ethylene glycol intoxication is not related to parent compound, but related to its end-products catalysed by alcohol dehydrogenase. Formic acid and oxalate are the most important toxic metabolites. The quick diagnosis of ethylene glycol intoxication could be not only by history taking, but also by findings of anion or osmolarity gap and needle-shape or envelope-shape calcium oxalate crystals in the urine analysis. Because of the competition of alcohol dehydrogenase by ethanol, which inhibits the production of toxic end-products of ethylene glycol, prompt treatment with ethanol decreases the mortality and provides a good prognosis. Quick diagnosis and early therapy with ethanol are the major roles in the management of ethylene glycol intoxication.

並列關鍵字

Ethylene glycol ； ethanol ； anion ； osmolarity gap ； oxalate crystal