- 期刊
某醫學中心三年糖化血色素與血糖值之關聯性分析
Three-year Related Analysis of Glycosylated Hemoglobin A1c and Blood Sugar in a Medical Center
摘要
研究背景：目前糖尿病監測是以血糖值及糖化血色素(HbA1c)為主要方式，兩者的關聯性也一直被研究探討著，本研究乃以北部某醫學中心，2003-2005年西醫門診就診糖尿病患者為對象，探討HbA1c與性別、年齡層、血糖值、高血脂及高血壓的關係。 研究方法：本研究三年糖尿病患共計14,936人，男性為7,460人，平均年齡為60.3±14.9歲；女性為7,476人，平均年齡為63.5±13.0歲。分析性統計方面，採用SPSS 10.0軟體中的變異數分析及多變項迴歸分析。 結果：分析性統計方面，在年齡層、性別、高血脂與高血壓等變項下，分析單一血糖值（飯前血清血糖值、飯後血清血糖值、飯前全血血糖值、飯飯全血血糖值）與HbA1c相關性，以飯後血清血糖值與HbA1c相關性最高(R2:0.499)，飯後全血血糖值最低(R2:0.238)；如果結合飯前及飯後血糖值來討論，以「飯前全血血糖值」及「飯後血清血糖值」關聯性最高(R2:0.579)；如果討論不同比例的飯前、飯後血糖值對於HbA1c的關係，在「飯前血清血糖值」及「飯後全血血糖值」模式下，則70%的飯前血清血糖值及30%飯後全血血糖值之新變項，與HbA1c關係有最高關聯性(R2:0.426)。 結論：門診追蹤糖尿病患者血糖監控時，本研究顯示HbA1c及飯後血清血糖值得相關性最高，如果基於實際的門診檢查運用，則建議以飯前血清血糖值或飯前全血血糖值為主。
關鍵字
無資料並列摘要
The blood sugar and HbA1c are the main indicators for diabetic control, and the relationship of both is continuously investigated. We collected the data from outpatients department at a medical center from 2003 to 2005 and analyzed the relationship of HbA1c and gender, ages, blood sugar, comorbidity of hypertension and hyperlipidemia. There are 14,936 persons (7,460 males and 7,476 females) in the 3-year study period. The mean age for male 60.2±14.9 years old; for female is 63.5±13.0 years old. Descriptive analysis demonstrates that the female diabetic patients distribute in a bell shape and there is a highest percent in the age group 61-65. For the male, the illustration shows a highest percent in the age 51-55 and then presents a decreased tendency. But, there is a peak in the age 71-75 not higher than the previous peak.. The HbA1c level declines as patients become older. Analytic statistics show the highest correlation for postprandial serum sugar and HbA1c (R^2: 0.499), but the postprandial whole blood sugar (R^2: 0.238) is the lowest.. If the fasting and postprandial blood sugars are put into the model simultaneously, the fasting whole sugar and postprandial serum blood sugar reveal the highest correlation with HbA1c (R^2: 0.579). Therefore, we create a new dependent variable by combining fasting and postprandial blood sugar in different ratio from the fasting serum and postprandial whole model. The 70% fasting and 30% postprandial blood sugar mode is most close to HbA1c (R^2: 0.426). Our study suggests physicians that the postprandial serum blood sugar and HbA1c are proper indicators for the diabetic control in the OPD.